Pathophysiology of Migraine

F. Michael Cutrer

doi:10.1055/s-0030-1249222

Seminars in Neurology, Table of Contents

Semin Neurol 2010; 30(2): 120-130
DOI: 10.1055/s-0030-1249222

Pathophysiology of Migraine

F. Michael Cutrer¹

¹Department of Neurology, Mayo Clinic, Rochester, Minnesota

Abstract

ABSTRACT

Our understanding of migraine pathophysiology is a work in progress. As more is learned about migraine, it seems that the probability of identifying a single unifying explanation for this common disorder becomes less and less. Although the neuroanatomy and elements of pain physiology underlying migraine attacks are probably shared pathophysiologic elements, the emerging complexity of migraine genetics suggests that the acute attack may be the final common expression of more than one type of initiating abnormality. After a brief summary of the neuroanatomic structures involved in the generation of migraine attacks and the traditional theories of migraine, the author focuses on the current understanding of migraine genetics and reviews recent data from the neuroimaging and the neurophysiology of migraine.

KEYWORDS

Migraine - pathophysiology - aura - central sensitization

Full Text

References

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F. Michael CutrerM.D.

Department of Neurology, Mayo Clinic

200 First Street SW, Rochester, MN 55905

Email: Cutrer.michael@mayo.edu